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Protein TRPV2 PDB 2f37.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TRPV2, VRL, VRL-1, VRL1, transient receptor potential cation channel subfamily V member 2
External IDs OMIM: 606676 MGI: 1341836 HomoloGene: 7993 GeneCards: TRPV2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TRPV2
Genomic location for TRPV2
Band 17p11.2 Start 16,415,542 bp[1]
End 16,437,003 bp[1]
RNA expression pattern
PBB GE TRPV2 219282 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 16.42 – 16.44 Mb Chr 17: 62.57 – 62.6 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene.[5][6]


This gene encodes an ion channel that is activated by high temperatures above 52 °C. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.[7]


TRPV2 was independently discovered by two research groups and described in 1999. It was identified in the lab of David Julius as a close homolog of TRPV1, the first identified thermosensitive ion channel.[5] The group of Itaru Kojima from Gunma University was looking for a protein which is responsible for the entry of calcium into cells in response to insulin-like growth factor-1 (IGF-1). Upon stimulation of cells with IGF-1 TRPV2 translocates towards and integrates into the cell membrane and increases intracellular calcium concentrations.[8]

Activators and inhibitors[edit]

TRPV2 is activated by high temperatures above 52 °C. Alternatively it can be activated at lower temperatures by chemicals, such as the research tool 2-APB,[9] the plant cannabinoid cannabidiol,[10] and probenecid.[11] It is blocked by ruthenium red and lanthanum.[8]

See also[edit]

  1. 11


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187688 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018507 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (Apr 1999). "A capsaicin-receptor homologue with a high threshold for noxious heat". Nature. 398 (6726): 436–41. doi:10.1038/18906. PMID 10201375. 
  6. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  7. ^ "Entrez Gene: TRPV2 transient receptor potential cation channel, subfamily V, member 2". 
  8. ^ a b Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (July 1999). "Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I". Nat. Cell Biol. 1 (3): 165–70. doi:10.1038/11086. PMID 10559903. 
  9. ^ Hu HZ, Gu Q, Wang C, et al. (August 2004). "2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3". J. Biol. Chem. 279 (34): 35741–8. doi:10.1074/jbc.M404164200. PMID 15194687. 
  10. ^ Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (June 2008). "TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons". J. Neurosci. 28 (24): 6231–8. doi:10.1523/JNEUROSCI.0504-08.2008. PMID 18550765. 
  11. ^ Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (September 2007). "Transient receptor potential V2 expressed in sensory neurons is activated by probenecid". Neurosci. Lett. 425 (2): 120–5. doi:10.1016/j.neulet.2007.08.035. PMID 17850966. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.