KCNA7

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Potassium voltage-gated channel, shaker-related subfamily, member 7
Identifiers
Symbols KCNA7 ; HAK6; KV1.7
External IDs OMIM176268 MGI96664 HomoloGene7791 IUPHAR: Kv1.7 ChEMBL: 2773 GeneCards: KCNA7 Gene
Orthologs
Species Human Mouse
Entrez 3743 16495
Ensembl ENSG00000104848 ENSMUSG00000038201
UniProt Q96RP8 Q17ST2
RefSeq (mRNA) NM_031886 NM_010596
RefSeq (protein) NP_114092 NP_034726
Location (UCSC) Chr 19:
49.57 – 49.58 Mb
Chr 7:
45.41 – 45.41 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily A member 7 also known as Kv1.7 is a protein that in humans is encoded by the KCNA7 gene.[1][1] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.[2]

References[edit]

  1. ^ a b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  2. ^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410. 

Further reading[edit]

  • Kashuba VI, Kvasha SM, Protopopov AI, et al. (2001). "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family.". Gene 268 (1–2): 115–22. doi:10.1016/S0378-1119(01)00423-1. PMID 11368907. 
  • Kalman K, Nguyen A, Tseng-Crank J, et al. (1998). "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7". J. Biol. Chem. 273 (10): 5851–7. doi:10.1074/jbc.273.10.5851. PMID 9488722. 
  • Ding Q, Zhao YY, Dong LY, et al. (2003). "[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]". Yi Chuan 25 (2): 129–32. PMID 15639836. 
  • Bardien-Kruger S, Wulff H, Arieff Z, et al. (2002). "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)". Eur. J. Hum. Genet. 10 (1): 36–43. doi:10.1038/sj.ejhg.5200739. PMID 11896454. 

External links[edit]