GJC1

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GJC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGJC1, CX45, GJA7, gap junction protein gamma 1
External IDsOMIM: 608655 MGI: 95718 HomoloGene: 4016 GeneCards: GJC1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GJC1
Genomic location for GJC1
Band17q21.31Start44,798,448 bp[1]
End44,830,816 bp[1]
RNA expression pattern
PBB GE GJA7 208460 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080383
NM_005497

NM_001159382
NM_001159383
NM_008122
NM_001359040

RefSeq (protein)

NP_001073852
NP_005488

NP_001152854
NP_001152855
NP_032148
NP_001345969

Location (UCSC)Chr 17: 44.8 – 44.83 MbChr 11: 102.8 – 102.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.[5][6]

Function[edit]

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182963 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034520 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kanter HL, Saffitz JE, Beyer EC (Dec 1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J Mol Cell Cardiol. 26 (7): 861–8. doi:10.1006/jmcc.1994.1103. PMID 7966354.
  6. ^ a b "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa".

Further reading[edit]

External links[edit]