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Gap junction protein, gamma 1, 45kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GJC1 ; CX45; GJA7
External IDs OMIM608655 MGI95718 HomoloGene4016 IUPHAR: 729 GeneCards: GJC1 Gene
RNA expression pattern
PBB GE GJA7 208460 at tn.png
More reference expression data
Species Human Mouse
Entrez 10052 14615
Ensembl ENSG00000182963 ENSMUSG00000034520
UniProt P36383 P28229
RefSeq (mRNA) NM_001080383 NM_001159382
RefSeq (protein) NP_001073852 NP_001152854
Location (UCSC) Chr 17:
44.8 – 44.83 Mb
Chr 11:
102.8 – 102.82 Mb
PubMed search [1] [2]

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.[1][2]


This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.[2]


  1. ^ Kanter HL, Saffitz JE, Beyer EC (Dec 1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J Mol Cell Cardiol 26 (7): 861–8. doi:10.1006/jmcc.1994.1103. PMID 7966354. 
  2. ^ a b "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa". 

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