BRSK2

BRSK2
Identifiers
Aliases	BRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, BR serine/threonine kinase 2, SAD-A
External IDs	OMIM: 609236; MGI: 1923020; HomoloGene: 123829; GeneCards: BRSK2; OMA:BRSK2 - orthologs
EC number	2.7.11.26
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,462,689 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,557,984 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; body of pancreas; ; right frontal lobe; ; ganglionic eminence; ; anterior cingulate cortex; ; Brodmann area 9; ; prefrontal cortex; ; C1 segment; ; nucleus accumbens; ; Amygdala;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; cerebellar cortex; ; prefrontal cortex; ; hippocampus proper; ; ganglionic eminence; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; ATPase binding; ATPase regulator activity; metal ion binding; kinase activity; protein kinase binding; magnesium ion binding; tau-protein kinase activity; protein serine/threonine kinase activity; ATP binding; tau protein binding;
Cellular component	centrosome; microtubule organizing center; perinuclear region of cytoplasm; cytoskeleton; nucleus; cytoplasm; endoplasmic reticulum; distal axon;
Biological process	actin cytoskeleton reorganization; neuron projection morphogenesis; ERAD pathway; phosphorylation; nervous system development; cell division; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; cell cycle; regulation of ATP-dependent activity; regulation of retrograde protein transport, ER to cytosol; exocytosis; apoptotic process; establishment of cell polarity; regulation of insulin secretion involved in cellular response to glucose stimulus; axonogenesis; protein phosphorylation; neuron differentiation; regulation of neuron projection development; intracellular signal transduction; regulation of axonogenesis; microtubule cytoskeleton organization involved in establishment of planar polarity; regulation of synaptic vesicle clustering;
	Sources:Amigo / QuickGO
Orthologs
	9024
	75770
	ENSG00000174672
	ENSMUSG00000053046
	Q8IWQ3
	Q69Z98
	NM_001256627; NM_001256629; NM_001256630; NM_001282218; NM_003957
	NM_001009929; NM_001009930; NM_001276763; NM_029426
	NP_001243556; NP_001243558; NP_001243559; NP_001269147; NP_003948
	NP_001009929; NP_001009930; NP_001263692; NP_083702
	Wikidata
View/Edit Human	View/Edit Mouse

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174672 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053046 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.
^ Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.
^ "Entrez Gene: BRSK2 BR serine/threonine kinase 2".

External links

Human BRSK2 genome location and BRSK2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174672 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053046 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9852686-5] Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.

[pmid9929968-6] Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.

[entrez-7] "Entrez Gene: BRSK2 BR serine/threonine kinase 2".

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[2]

[3]

[4]

[5]

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[7]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading

External links