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Type II keratin

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This is an old revision of this page, as edited by Niceguyedc (talk | contribs) at 00:18, 29 December 2019 (v2.02 - Repaired 2 links to disambiguation pages - (You can help) - CK1, CK3). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Type II keratins (or Type II cytokeratins) constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.

Type II cytokeratins are encoded on chromosome 12q and encompasses: CK1, CK2, CK3, CK4, CK5, CK6, CK7 and CK8. Their molecular weight ranges from 52 kDa (CK8) to 67 kDa (CK18).

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