PKMYT1

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PKMYT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKMYT1, MYT1, PPP1R126, protein kinase, membrane associated tyrosine/threonine 1
External IDsOMIM: 602474; MGI: 2137630; HomoloGene: 31227; GeneCards: PKMYT1; OMA:PKMYT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258450
NM_001258451
NM_004203
NM_182687

NM_023058

RefSeq (protein)

NP_001245379
NP_001245380
NP_004194
NP_872629
NP_004194.3

NP_075545

Location (UCSC)Chr 16: 2.97 – 2.98 MbChr 17: 23.95 – 23.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.[5][6][7]

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Interactions

PKMYT1 has been shown to interact with PIN1[8] and STEAP3.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127564Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023908Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol Cell Biol. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
  6. ^ a b Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc Natl Acad Sci U S A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
  7. ^ "Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1".
  8. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5). UNITED STATES: 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Further reading

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