PRKCH

PRKCH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FK9, 3TXO
Identifiers
Aliases	PRKCH, PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta
External IDs	OMIM: 605437; MGI: 97600; HomoloGene: 84384; GeneCards: PRKCH; OMA:PRKCH - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	61,550,976 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	73,824,959 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; granulocyte; ; blood; ; lymph node; ; tonsil; ; upper lobe of left lung; ; thymus; ; right lung; ; visceral pleura; ; epithelium of colon;
	Top expressed in
	right lung lobe; ; esophagus; ; hair follicle; ; gastrula; ; endothelial cell of lymphatic vessel; ; transitional epithelium of urinary bladder; ; blood; ; thymus; ; lip; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase C activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; calcium-independent protein kinase C activity; enzyme binding; ATP binding; protein binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; plasma membrane; extracellular exosome; intracellular anatomical structure;
Biological process	positive regulation of B cell receptor signaling pathway; cell differentiation; intracellular signal transduction; phosphorylation; regulation of bicellular tight junction assembly; positive regulation of keratinocyte differentiation; negative regulation of glial cell apoptotic process; protein kinase C signaling; platelet activation; protein phosphorylation; positive regulation of macrophage derived foam cell differentiation; positive regulation of NF-kappaB transcription factor activity; peptidyl-serine phosphorylation; positive regulation of glial cell proliferation; signal transduction; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5583
	18755
	ENSG00000027075
	ENSMUSG00000021108
	P24723
	P23298
	NM_006255
	NM_008856; NM_001313977
	NP_006246
	NP_001300906; NP_032882
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000027075 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021108 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bacher N, Zisman Y, Berent E, Livneh E (Feb 1991). "Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart". Mol Cell Biol. 11 (1): 126–33. PMC 359602. PMID 1986216.
^ Bacher N, Zisman Y, Berent E, Livneh E (Apr 1992). "Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart". Mol Cell Biol. 12 (3): 1404. PMC 369574. PMID 1545821.
^ "Entrez Gene: PRKCH protein kinase C, eta".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading