RPS6KB2

RPS6KB2
Identifiers
Aliases	RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, ribosomal protein S6 kinase B2, S6KB, S6KI(2), S6Kbeta
External IDs	OMIM: 608939; MGI: 1927343; HomoloGene: 68374; GeneCards: RPS6KB2; OMA:RPS6KB2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,435,401 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; granulocyte; ; body of stomach; ; apex of heart; ; right lobe of liver; ; right hemisphere of cerebellum; ; anterior pituitary; ; muscle of thigh; ; mucosa of transverse colon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; peptide binding; kinase activity; protein serine/threonine kinase activity; ATP binding; ribosomal protein S6 kinase activity;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	intracellular signal transduction; protein biosynthesis; phosphorylation; protein phosphorylation; positive regulation of translational initiation; signal transduction; protein kinase B signaling; TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	6199
	58988
	ENSG00000175634
	ENSMUSG00000024830
	Q9UBS0
	Q9Z1M4
	NM_001007071; NM_003952
	NM_021485
	NP_003943
	NP_067460.1
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.^[4]^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175634 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun. 253 (2): 470–476. doi:10.1006/bbrc.1998.9784. PMID 9878560.
^ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J Biol Chem. 273 (46): 30061–30064. doi:10.1074/jbc.273.46.30061. PMID 9804755.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)