2CBCB-NBOMe: Difference between revisions

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m NBOMe-2C-I, was not discoved by the same research team at Purdue, it was discover in Germany in 2003 by Ralf Heim. -Removed erroneus part of sentence
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{{Article for deletion/dated|page=PageName|timestamp=20120311062717|year=2012|month=March|day=11|substed=yes}}
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| verifiedrevid = 452168959
| verifiedrevid = 452168959
| IUPAC_name = N-(2-methoxybenzyl)-1-[(7''R'')-3-bromo-2,5-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methanamine
| IUPAC_name = N-(2-methoxybenzyl)-1-[(7''R'')-3-bromo-2,5-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methanamine

Revision as of 06:27, 11 March 2012

2CBCB-NBOMe
Legal status
Legal status
  • In general: legal
Identifiers
  • N-(2-methoxybenzyl)-1-[(7R)-3-bromo-2,5-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methanamine
ChemSpider
Chemical and physical data
FormulaC19H22BrNO3
Molar mass392.286 g/mol g·mol−1
3D model (JSmol)
  • COc1ccccc1CNCC3c2c(C3)c(OC)c(Br)cc2OC
  • InChI=1S/C19H22BrNO3/c1-22-16-7-5-4-6-12(16)10-21-11-13-8-14-18(13)17(23-2)9-15(20)19(14)24-3/h4-7,9,13,21H,8,10-11H2,1-3H3/t13-/m0/s1 checkY
  • Key:CLSBQRBXTFTLEX-ZDUSSCGKSA-N checkY
  (verify)

2CBCB-NBOMe (NBOMe-TCB-2) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2007 at Purdue University as part of the ongoing research program of the team led by David Nichols focusing on the mapping of the specific amino acid residues responsible for ligand binding to the 5HT2A receptor. 2CBCB-NBOMe acts as a potent and selective agonist for the 5-HT2A and 5-HT2C receptors, with a Ki of 0.27nM at the human 5-HT2A receptor, a similar potency to other agonists such as TCB-2, NBOMe-2C-I and bromodragonfly[1]


See also

References

  1. ^ Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.


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