Ethylone

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Ethylone
Bk-MDEA.svg
Systematic (IUPAC) name
(RS)-1-(1,3-benzodioxol-5-yl)-2-(ethylamino)propan-1-one
Clinical data
Pregnancy
category
  • N (US)
Routes of
administration
Oral, nasal, IV
Legal status
Legal status
Identifiers
CAS Number 1112937-64-0 YesY
PubChem CID 57252245
ChemSpider 21106271 N
UNII L91C78FW96
Chemical data
Formula C12H15NO3
Molar mass 221.2524 g/mol
Chirality Racemic mixture
 NYesY (what is this?)  (verify)

Ethylone, also known as 3,4-methylenedioxy-N-ethylcathinone (MDEC, βk-MDEA), is recreational designer drug classified as an entactogen, stimulant, and psychedelic of the phenethylamine, amphetamine, and cathinone chemical classes. It is the β-keto analogue of MDEA ("Eve"). Ethylone has only a short history of human use and is reported to be less potent than its relative methylone.[citation needed] In the United States, it began to be found in cathinone products in late 2011.[1]

Very little data exists about the pharmacological properties, metabolism, and toxicity of ethylone, but several ethylone-related deaths have been reported.[1]

Pharmacokinetics[edit]

Analysis of human and rat urine for the metabolites of bk-amphetamines suggested that ethylone was degraded in the following metabolic steps:[2]

  1. N-deethylation to the primary amine.
  2. Reduction of the keto moiety to the respective alcohol.

Legal Status[edit]

As of October 2015 Ethylone is a controlled substance in China.[3]

See also[edit]

References[edit]

  1. ^ a b Dayong Lee; Chris W. Chronister; Jennifer Hoyer; Bruce A. Goldberger (September 2015). "Ethylone-Related Deaths: Toxicological Findings". Journal of Analytical Toxicology. 39 (7): 567–571. doi:10.1093/jat/bkv053. PMID 26025164. 
  2. ^ Meyer, Markus R; Jens Wilhelm; Frank T. Peters; Hans H. Maurer (June 2010). "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry". Analytical and Bioanalytical Chemistry. 397 (3): 1225–1233. doi:10.1007/s00216-010-3636-5. PMID 20333362. 
  3. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 

External links[edit]