RPS6KA2

RPS6KA2
Identifiers
Aliases	RPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2
External IDs	OMIM: 601685; MGI: 1342290; HomoloGene: 100680; GeneCards: RPS6KA2; OMA:RPS6KA2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	166,906,451 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,570,714 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; lower lobe of lung; ; internal globus pallidus; ; dorsal motor nucleus of vagus nerve; ; inferior ganglion of vagus nerve; ; C1 segment; ; optic nerve; ; right lung; ; corpus callosum; ; superior vestibular nucleus;
	Top expressed in
	granulocyte; ; muscle of thigh; ; neural layer of retina; ; tail of embryo; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; genital tubercle; ; lens; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; magnesium ion binding; kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleus;
Biological process	phosphorylation; negative regulation of cell cycle; protein phosphorylation; positive regulation of apoptotic process; negative regulation of cell population proliferation; signal transduction; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	6196
	20112
	ENSG00000071242
	ENSMUSG00000023809
	Q15349
	Q9WUT3
	NM_001006932; NM_021135; NM_001318936; NM_001318937; NM_001318938
	NM_011299
	NP_001006933; NP_001305865; NP_001305866; NP_001305867; NP_066958
	NP_035429
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.^[5]^[6]

Template:PBB Summary

Interactions

RPS6KA2 has been shown to interact with MAPK3^[7]^[8] and MAPK1.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023809 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol. 266 (2 Pt 1): C351–9. PMID 8141249.
^ "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2".
^ ^a ^b Roux, Philippe P; Richards Stephanie A; Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity". Mol. Cell. Biol. 23 (14). United States: 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN 0270-7306. PMC 162206. PMID 12832467. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ ^a ^b Zhao, Y; Bjorbaek C; Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. 271 (47). UNITED STATES: 29773–9. doi:10.1074/jbc.271.47.29773. ISSN 0021-9258. PMID 8939914. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading