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Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene .[ 5] [ 6] [ 7] [ 8] phosphatidylinositol 3-kinase-related kinase protein family.
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[ 8]
SMG1 (gene) has been shown to interact with PRKCI [ 9] UPF1 .[ 10]
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Activity Regulation Classification Kinetics Types
