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Aliases SMG1, 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase
External IDs MGI: 1919742 HomoloGene: 56697 GeneCards: SMG1
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 18.8 – 18.93 Mb Chr 7: 118.13 – 118.24 Mb
PubMed search [1] [2]
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Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[3][4][5][6] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.


This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[6]


SMG1 (gene) has been shown to interact with PRKCI[7] and UPF1.[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
  4. ^ Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269. 
  5. ^ Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728. 
  6. ^ a b "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1". 
  7. ^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. PMC 230983Freely accessible. PMID 8524286. 
  8. ^ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771Freely accessible. PMID 11544179. 

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