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Revision as of 13:45, 1 August 2023 by Heavy Grasshopper(talk | contribs)(Adding local short description: "Protein-coding gene in humans", overriding Wikidata description "protein-coding gene in the species Homo sapiens")
Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1protein.[5] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[5]
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Miki T, Suzuki M, Shibasaki T, et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1". Nat. Med. 8 (5): 466–472. doi:10.1038/nm0502-466. PMID11984590. S2CID32502965.
Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID12217870. S2CID6960591.
Emanuele E, Falcone C, Carabela M, et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion". Int. J. Mol. Med. 12 (4): 509–12. doi:10.3892/ijmm.12.4.509. PMID12964027.