KCNK1

KCNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UKM
Identifiers
Aliases	KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDs	OMIM: 601745; MGI: 109322; HomoloGene: 1691; GeneCards: KCNK1; OMA:KCNK1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	233,672,514 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	126,757,424 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; endothelial cell; ; cerebellar hemisphere; ; orbitofrontal cortex; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; cartilage tissue; ; corpus epididymis; ; cardiac muscle tissue of right atrium;
	Top expressed in
	seminal vesicula; ; molar; ; choroid plexus of fourth ventricle; ; lobe of cerebellum; ; lobe of prostate; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; cerebellar vermis; ; Epithelium of choroid plexus; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel activity; potassium ion leak channel activity; voltage-gated potassium channel activity; inward rectifier potassium channel activity; potassium channel activity; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; recycling endosome; perikaryon; endosome; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; synapse; inward rectifier potassium channel complex; brush border membrane; cell junction; dendrite; potassium channel complex; apical plasma membrane; cytoplasmic vesicle; intracellular membrane-bounded organelle;
Biological process	sodium ion transmembrane transport; response to nicotine; ion transport; potassium ion transport; cardiac conduction; potassium ion transmembrane transport; regulation of resting membrane potential; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3775
	16525
	ENSG00000135750
	ENSMUSG00000033998
	O00180
	O08581
	NM_002245
	NM_008430
	NP_002236
	NP_032456
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.^[5]^[6]^[7]

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033998 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
^ ^a ^b "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily". J. Mol. Med. 76 (1): 13–20. doi:10.1007/s109-1998-8100-0. PMID 9462864.
Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. Renal Physiol. 279 (5): F793–801. doi:10.1152/ajprenal.2000.279.5.F793. PMID 11053038.
Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
Lesage F; Guillemare E; Fink M; et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure". EMBO J. 15 (5): 1004–11. doi:10.1002/j.1460-2075.1996.tb00437.x. PMC 449995. PMID 8605869. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lesage F; Reyes R; Fink M; et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23): 6400–7. PMC 452465. PMID 8978667. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Orias M; Velázquez H; Tung F; et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments". Am. J. Physiol. 273 (4 Pt 2): F663–6. PMID 9362344. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wang Z; Yue L; White M; et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle". Circulation. 98 (22): 2422–8. doi:10.1161/01.cir.98.22.2422. PMID 9832487. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Medhurst AD; Rennie G; Chapman CG; et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear". Hear. Res. 181 (1–2): 20–6. doi:10.1016/S0378-5955(03)00162-X. PMID 12855359.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rajan S; Plant LD; Rabin ML; et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell. 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

External links

KCNK1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135750 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033998 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661042-5] Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.

[entrez-7] "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

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KCNK1

See also

References

Further reading

External links