Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1protein.[5] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[5]
Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)". Genomics. 30 (1): 102–104. doi:10.1006/geno.1995.0018. PMID8595887.
Suzuki M; Kotake K; Fujikura K; et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria". Biochem. Biophys. Res. Commun. 241 (3): 693–697. doi:10.1006/bbrc.1997.7891. PMID9434770. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel". Gene. 211 (1): 71–78. doi:10.1016/S0378-1119(98)00086-9. PMID9573340.
Kono Y; Horie M; Takano M; et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A". Pflügers Arch. 440 (5): 692–698. doi:10.1007/s004240000315. PMID11007308. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)