KCNIP1

KCNIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S1E, 2I2R, 2NZ0
Identifiers
Aliases	KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDs	OMIM: 604660; MGI: 1917607; HomoloGene: 22824; GeneCards: KCNIP1; OMA:KCNIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	170,736,632 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,943,152 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; anterior cingulate cortex; ; caudate nucleus; ; amygdala; ; right frontal lobe; ; prefrontal cortex; ; hypothalamus; ; putamen; ; testicle; ; dorsolateral prefrontal cortex;
	Top expressed in
	habenula; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; ventromedial nucleus; ; superior colliculus; ; lobe of cerebellum; ; cerebellar vermis; ; paraventricular nucleus of hypothalamus; ; lateral septal nucleus; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; potassium channel regulator activity; potassium channel activity; protein binding; metal ion binding; voltage-gated ion channel activity;
Cellular component	cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; voltage-gated potassium channel complex; plasma membrane; cell projection; dendrite; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; regulation of potassium ion transmembrane transport; potassium ion transmembrane transport; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	30820
	70357
	ENSG00000182132
	ENSMUSG00000053519
	Q9NZI2
	Q9JJ57
	NM_001034837; NM_001034838; NM_001278339; NM_001278340; NM_014592
	NM_001190885; NM_001190886; NM_001290690; NM_027398; NM_001363115
	NP_001030009; NP_001030010; NP_001265268; NP_001265269; NP_055407
	NP_001177814; NP_001177815; NP_001277619; NP_081674; NP_001350044
	Wikidata
View/Edit Human	View/Edit Mouse

K_v channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.^[5]^[6]

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182132 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964.
^ ^a ^b "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Bähring R; Dannenberg J; Peters HC; et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–23894. doi:10.1074/jbc.M101320200. PMID 11287421. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Nakamura TY; Nandi S; Pountney DJ; et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–209. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kutsenko AS; Gizatullin RZ; Al-Amin AN; et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–3170. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Shibata R; Misonou H; Campomanes CR; et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–36454. doi:10.1074/jbc.M306142200. PMID 12829703. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Van Hoorick D; Raes A; Keysers W; et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci. 24 (2): 357–366. doi:10.1016/S1044-7431(03)00174-X. PMID 14572458. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Scannevin RH; Wang K; Jow F; et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1". Neuron. 41 (4): 587–598. doi:10.1016/S0896-6273(04)00049-2. PMID 14980207. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–724. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–610. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics. 86 (5): 581–593. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.
Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer". Nat. Struct. Mol. Biol. 13 (11): 987–995. doi:10.1038/nsmb1164. PMC 3018330. PMID 17057713.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005). "Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway". J. Cell Biol. 171 (3): 459–469. doi:10.1083/jcb.200506005. PMC 2171252. PMID 16260497.
Venn N, Haynes LP, Burgoyne RD (2008). "Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells". Biochem. J. 413 (1): 71–80. doi:10.1042/BJ20080441. PMC 2474559. PMID 18393943.

External links

KCNIP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182132 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053519 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10676964-5] An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964.

[entrez-6] "Entrez Gene: KCNIP1 Kv channel interacting protein 1".

[pmid17311005-7] Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

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KCNIP1

Function

See also

References

Further reading

External links