Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3gene.[5][6][7][8]
This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.[8]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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^Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID9721223.
^O'Kelly, Ita; Butler Margaret H; Zilberberg Noam; Goldstein Steve A N (Nov 2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4). United States: 577–88. doi:10.1016/S0092-8674(02)01040-1. ISSN0092-8674. PMID12437930. S2CID15898814.
Buist SC, Cherrington NJ, Choudhuri S, et al. (2002). "Gender-specific and developmental influences on the expression of rat organic anion transporters". J. Pharmacol. Exp. Ther. 301 (1): 145–51. doi:10.1124/jpet.301.1.145. PMID11907168.
Barbuti A, Ishii S, Shimizu T, et al. (2002). "Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor". Am. J. Physiol. Heart Circ. Physiol. 282 (6): H2024–30. doi:10.1152/ajpheart.00956.2001. PMID12003807.
O'Kelly I, Butler MH, Zilberberg N, Goldstein SA (2002). "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals". Cell. 111 (4): 577–88. doi:10.1016/S0092-8674(02)01040-1. PMID12437930. S2CID15898814.
Aslamkhan A, Han YH, Walden R, et al. (2003). "Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells". Am. J. Physiol. Renal Physiol. 285 (4): F775–83. doi:10.1152/ajprenal.00140.2003. PMID12837685.
Hsu K, Seharaseyon J, Dong P, et al. (2004). "Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel". Mol. Cell. 14 (2): 259–67. doi:10.1016/S1097-2765(04)00183-2. PMID15099524.
Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID15197476. S2CID11439105.
Bai X, Greenwood SL, Glazier JD, et al. (2005). "Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells". J. Soc. Gynecol. Investig. 12 (2): 77–83. doi:10.1016/j.jsgi.2004.08.004. PMID15695101. S2CID20173840.