Lens fiber major intrinsic protein

MIP
Identifiers
Aliases	MIP, AQP0, CTRCT15, LIM1, MIP26, MP26, major intrinsic protein of lens fiber
External IDs	OMIM: 154050; MGI: 96990; HomoloGene: 40627; GeneCards: MIP; OMA:MIP - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 56,449,502 bp End 56,469,166 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 D3|10 76.49 cM Start 128,061,707 bp End 128,067,681 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right lobe of liver apex of heart right adrenal cortex right testis left testis left adrenal gland body of pancreas left adrenal cortex Top expressed in lens epithelium of lens set of lens fibers neural layer of retina ciliary body embryo morula tail of embryo blastocyst conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calmodulin binding structural constituent of eye lens water channel activity channel activity Cellular component integral component of membrane membrane plasma membrane cell junction apical plasma membrane endoplasmic reticulum gap junction integral component of plasma membrane Biological process response to stimulus water transport ion transmembrane transport lens development in camera-type eye protein homotetramerization visual perception positive regulation of cell adhesion gap junction-mediated intercellular transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4284 17339 Ensembl ENSG00000135517 ENSMUSG00000025389 UniProt P30301 P51180 RefSeq (mRNA) NM_012064 NM_008600 RefSeq (protein) NP_036196 NP_032626 Location (UCSC) Chr 12: 56.45 – 56.47 Mb Chr 10: 128.06 – 128.07 Mb PubMed search
Wikidata
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Lens fiber major intrinsic protein is a protein that in humans is encoded by the MIP gene.

Function

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.

Further reading

• Chepelinsky AB, Piatigorsky J, Pisano MM, et al. (1991). "Lens protein gene expression: alpha-crystallins and MIP". Lens and Eye Toxicity Research. 8 (2–3): 319–44. PMID 1911643.
• Griffin CS, Shiels A (1992). "In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14". Cytogenet. Cell Genet. 61 (1): 8–9. doi:10.1159/000133360. PMID 1505237.
• Girsch SJ, Peracchia C (1992). "Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26". Curr. Eye Res. 10 (9): 839–49. doi:10.3109/02713689109013880. PMID 1790714.
• Lampe PD, Johnson RG (1991). "Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes". Eur. J. Biochem. 194 (2): 541–7. doi:10.1111/j.1432-1033.1990.tb15650.x. PMID 2176601.
• Manenti S, Dunia I, Benedetti EL (1990). "Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated". FEBS Lett. 262 (2): 356–8. doi:10.1016/0014-5793(90)80228-B. PMID 2335219. S2CID 40684631.
• Peracchia C, Girsch SJ (1991). "Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26". Lens and Eye Toxicity Research. 6 (4): 613–21. PMID 2487274.
• Saito F, Sasaki S, Chepelinsky AB, et al. (1994). "Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH". Cytogenet. Cell Genet. 68 (1–2): 45–8. doi:10.1159/000133885. PMID 7525161.
• Jarvis LJ, Louis CF (1996). "Purification and oligomeric state of the major lens fiber cell membrane proteins". Curr. Eye Res. 14 (9): 799–808. doi:10.3109/02713689508995802. PMID 8529419.
• Wang XY, Ohtaka-Maruyama C, Pisano MM, et al. (1996). "Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene". Gene. 167 (1–2): 321–5. doi:10.1016/0378-1119(95)00637-0. PMID 8566800.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Prabhakaram M, Katz ML, Ortwerth BJ (1997). "Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes". Mech. Ageing Dev. 91 (1): 65–78. doi:10.1016/0047-6374(96)01781-2. PMID 8910261. S2CID 53227438.
• Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
• Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB (1998). "Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene". Nucleic Acids Res. 26 (2): 407–14. doi:10.1093/nar/26.2.407. PMC 147274. PMID 9421492.
• Dunia I, Recouvreur M, Nicolas P, et al. (1998). "Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling". J. Cell Sci. 111 (15): 2109–20. PMID 9664032.
• Schey KL, Fowler JG, Shearer TR, David L (1999). "Modifications to rat lens major intrinsic protein in selenite-induced cataract". Invest. Ophthalmol. Vis. Sci. 40 (3): 657–67. PMID 10067969.
• Schey KL, Little M, Fowler JG, Crouch RK (2000). "Characterization of human lens major intrinsic protein structure". Invest. Ophthalmol. Vis. Sci. 41 (1): 175–82. PMID 10634618.
• Berry V, Francis P, Kaushal S, et al. (2000). "Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q". Nat. Genet. 25 (1): 15–7. doi:10.1038/75538. PMID 10802646. S2CID 22878198.