CatSper3

CATSPER3
Identifiers
Aliases	CATSPER3, CACRC, CatSper3, cation channel sperm associated 3
External IDs	OMIM: 609120; MGI: 1924106; HomoloGene: 12658; GeneCards: CATSPER3; OMA:CATSPER3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	135,011,696 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,956,811 bp
RNA expression pattern
	Top expressed in
	sperm; ; right testis; ; left testis; ; testicle; ; gonad; ; gastrocnemius muscle; ; muscle of thigh; ; right uterine tube; ; mucosa of transverse colon; ; gastric mucosa;
	Top expressed in
	spermatid; ; seminiferous tubule; ; embryo; ; spermatocyte; ; embryo; ; primary oocyte; ; muscle of thigh; ; zygote; ; proximal tubule; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium channel activity; voltage-gated ion channel activity; ion channel activity; cation channel activity;
Cellular component	integral component of membrane; CatSper complex; cell projection; membrane; plasma membrane; cilium; acrosomal vesicle; endoplasmic reticulum; motile cilium;
Biological process	flagellated sperm motility; cell differentiation; membrane depolarization during action potential; sodium ion transport; regulation of ion transmembrane transport; ion transport; multicellular organism development; ion transmembrane transport; calcium ion transmembrane transport; transmembrane transport; spermatogenesis; sperm-egg recognition; sperm capacitation; calcium ion transport; response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	347732
	76856
	ENSG00000152705
	ENSMUSG00000021499
	Q86XQ3
	Q80W99
	NM_178019
	NM_001252487; NM_001252488; NM_029772
	NP_821138
	NP_001239416; NP_001239417; NP_084048
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.^[5]^[6]^[7]^[8] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152705 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021499 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162.
^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152705 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021499 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12646162-5] Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162.

[pmid12932298-6] Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.

[pmid17227845-7] Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.

[pmid16382101-8] Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

[IUPHAR-DB-9] *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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