Casein kinase 2

protein kinase CK2 complex
Identifiers
Aliases	casein kinase II complexGO:0005956casein kinase 2Casein Kinase II
External IDs	GeneCards: [1]; OMA:- orthologs
Orthologs Species Human Mouse Entrez n/a n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a
Wikidata
View/Edit Human

The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.

casein kinase 2, alpha 1 polypeptide Identifiers Symbol CSNK2A1 NCBI gene 1457 HGNC 2457 OMIM 115440 RefSeq NM_001895 UniProt P68400 Other data EC number 2.7.11.1 Locus Chr. 20 p13 Search for Structures Swiss-model Domains InterPro

casein kinase 2, alpha prime polypeptide Identifiers Symbol CSNK2A2 NCBI gene 1459 HGNC 2459 OMIM 115442 RefSeq NM_001896 UniProt P19784 Other data EC number 2.7.11.1 Locus Chr. 16 [2] Search for Structures Swiss-model Domains InterPro

casein kinase 2, beta polypeptide Identifiers Symbol CSNK2B NCBI gene 1460 HGNC 2460 OMIM 115441 RefSeq NM_001320 UniProt P67870 Other data EC number 2.7.11.1 Locus Chr. 6 p21.3 Search for Structures Swiss-model Domains InterPro

See also

• CSNK2A1
• CSNK2A2
• Casein kinase 1 — a distinct protein kinase family