KCNK12

KCNK12
Identifiers
Aliases	KCNK12, K2p12.1, THIK-2, THIK2, potassium two pore domain channel subfamily K member 12
External IDs	OMIM: 607366; MGI: 2684043; HomoloGene: 11107; GeneCards: KCNK12; OMA:KCNK12 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p16.3 Start 47,509,290 bp End 47,570,985 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E4 Start 88,053,229 bp End 88,105,422 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb trigeminal ganglion spinal ganglia inferior olivary nucleus cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum sural nerve primary visual cortex Top expressed in primary visual cortex cerebellar cortex superior frontal gyrus embryo granulocyte dentate gyrus of hippocampal formation granule cell neural layer of retina anterior horn of spinal cord olfactory bulb hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity Cellular component integral component of membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport stabilization of membrane potential potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56660 210741 Ensembl ENSG00000184261 ENSMUSG00000050138 UniProt Q9HB15 Q76M80 RefSeq (mRNA) NM_022055 NM_199251 RefSeq (protein) NP_071338 NP_954859 Location (UCSC) Chr 2: 47.51 – 47.57 Mb Chr 17: 88.05 – 88.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K_2P12.1, is a potassium channel containing two pore-forming P domains.

See also

• Tandem pore domain potassium channel

Further reading

• Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
• Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Farkkila M, Hamalainen E, Kaprio J, Kaunisto MA (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Theilig F, Goranova I, Hirsch JR, Wieske M, ÜNsal S, Bachmann S, Veh RW, Derst C (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. Biochem. 21 (1–3): 63–74. doi:10.1159/000113748. PMID 18209473. S2CID 26356698.

External links

• KCNK12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)