KvLQT3

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KCNQ3
Identifiers
Aliases KCNQ3, BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3
External IDs OMIM: 602232 MGI: 1336181 HomoloGene: 20949 GeneCards: 3786
Genetically Related Diseases
Disease Name References
coronary artery disease
RNA expression pattern
PBB GE KCNQ3 206573 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204824
NM_004519

NM_152923

RefSeq (protein)

NP_001191753.1
NP_004510.1

NP_690887.2

Location (UCSC) Chr 8: 132.12 – 132.48 Mb Chr 15: 65.99 – 66.29 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[1]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[1]

Interactions[edit]

KvLQT3 has been shown to interact with KCNQ5.[2]

References[edit]

  1. ^ a b "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3". 
  2. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience (United States) 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.