KCNQ5

KCNQ5
Identifiers
Aliases	KCNQ5, Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDs	OMIM: 607357; MGI: 1924937; HomoloGene: 28270; GeneCards: KCNQ5; OMA:KCNQ5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,198,853 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	22,032,166 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; Brodmann area 23; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; quadriceps femoris muscle; ; Brodmann area 46; ; vastus lateralis muscle; ; superior frontal gyrus;
	Top expressed in
	primary motor cortex; ; olfactory tubercle; ; nucleus accumbens; ; piriform cortex; ; sternocleidomastoid muscle; ; prefrontal cortex; ; temporal muscle; ; globus pallidus; ; digastric muscle; ; temporal lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; potassium channel activity; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; calmodulin binding;
Cellular component	membrane; clathrin coat; integral component of membrane; integral component of plasma membrane; voltage-gated potassium channel complex; plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56479
	226922
	ENSG00000185760
	ENSMUSG00000028033
	Q9NR82
	Q9JK45
	NM_001160130; NM_001160132; NM_001160133; NM_001160134; NM_019842
	NM_001160139; NM_023872; NM_001310477
	NP_001153602; NP_001153604; NP_001153605; NP_001153606; NP_062816
	NP_001153611; NP_001297406; NP_076361
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

Interactions

KCNQ5 has been shown to interact with KvLQT3.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
^ "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".
^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2). United States: 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

KCNQ5

Interactions

See also

References

Further reading