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Revision as of 13:13, 22 July 2016 by Boghog(talk | contribs)(removed no longer needed PBB controls and templates; consistent citation formatting; removed further reading citations not specific to this gene)
Potassium voltage-gated channel subfamily S member 3 is a protein that in humans is encoded by the KCNS3gene.[5][6][7]
Function
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.[7]
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^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID16382104.
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Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–34. doi:10.1006/bbrc.1998.9072. PMID9704029.
Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–83. doi:10.1007/s00439-005-1256-5. PMID15714333.