MAP2K4

MAP2K4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ALN, 3ALO, 3VUT
Identifiers
Aliases	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4
External IDs	OMIM: 601335; MGI: 1346869; HomoloGene: 48159; GeneCards: MAP2K4; OMA:MAP2K4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	12,143,830 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	65,679,123 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; Brodmann area 46; ; postcentral gyrus; ; orbitofrontal cortex; ; Pars compacta; ; middle temporal gyrus; ; superior frontal gyrus; ; prefrontal cortex; ; Achilles tendon; ; Brodmann area 23;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; genital tubercle; ; facial motor nucleus; ; superior frontal gyrus; ; primary visual cortex; ; anterior horn of spinal cord; ; secondary oocyte; ; dorsomedial hypothalamic nucleus; ; granulocyte; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; MAP kinase kinase activity; JUN kinase kinase activity; protein serine/threonine kinase activity; mitogen-activated protein kinase kinase kinase binding;
Cellular component	cytoplasm; nucleus; dendrite cytoplasm; cytosol; perikaryon; axon;
Biological process	phosphorylation; MAPK cascade; protein phosphorylation; cellular response to mechanical stimulus; response to wounding; peptidyl-tyrosine phosphorylation; signal transduction; negative regulation of motor neuron apoptotic process; apoptotic process; cell growth involved in cardiac muscle cell development; cellular response to sorbitol; positive regulation of smooth muscle cell apoptotic process; JNK cascade; positive regulation of protein phosphorylation; positive regulation of neuron apoptotic process; positive regulation of DNA replication; positive regulation of apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; Fc-epsilon receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6416
	26398
	ENSG00000065559
	ENSMUSG00000033352
	P45985
	P47809
	NM_001281435; NM_003010
NM_009157; NM_001316367; NM_001316368; NM_001316369; NM_001362739;
	NM_001362740
	NP_001268364; NP_003001
NP_001303296; NP_001303297; NP_001303298; NP_033183; NP_001349668;
	NP_001349669
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.^[5]

Template:PBB Summary

Interactions

MAP2K4 has been shown to interact with FLNC,^[6] MAPK8,^[7]^[8]^[9]^[10]^[11] MAPK8IP3^[12]^[13] and AKT1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033352 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M (May 1995). "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2". Science. 268 (5208): 286–90. Bibcode:1995Sci...268..286L. doi:10.1126/science.7716521. PMID 7716521.
^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (January 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5). UNITED STATES: 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Lee, Clement M; Onésime Djamila; Reddy C Damodara; Dhanasekaran N; Reddy E Premkumar (October 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proc. Natl. Acad. Sci. U.S.A. 99 (22). United States: 14189–94. Bibcode:2002PNAS...9914189L. doi:10.1073/pnas.232310199. ISSN 0027-8424. PMC 137859. PMID 12391307. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ ^a ^b Park, Hee-Sae; Kim Mi-Sung; Huh Sung-Ho; Park Jihyun; Chung Jongkyeong; Kang Sang Sun; Choi Eui-Ju (January 2002). "Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation". J. Biol. Chem. 277 (4). United States: 2573–8. doi:10.1074/jbc.M110299200. ISSN 0021-9258. PMID 11707464. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Chen, Z; Cobb M H (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19). United States: 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Tournier, C; Whitmarsh A J; Cavanagh J; Barrett T; Davis R J (July 1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 (14). UNITED STATES: 7337–42. Bibcode:1997PNAS...94.7337T. doi:10.1073/pnas.94.14.7337. ISSN 0027-8424. PMC 23822. PMID 9207092. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Cheng, J; Yang J; Xia Y; Karin M; Su B (April 2000). "Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation". Mol. Cell. Biol. 20 (7). UNITED STATES: 2334–42. doi:10.1128/MCB.20.7.2334-2342.2000. ISSN 0270-7306. PMC 85399. PMID 10713157. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Ito, M; Yoshioka K; Akechi M; Yamashita S; Takamatsu N; Sugiyama K; Hibi M; Nakabeppu Y; Shiba T; Yamamoto K I (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11). UNITED STATES: 7539–48. doi:10.1128/mcb.19.11.7539. ISSN 0270-7306. PMC 84763. PMID 10523642. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43). United States: 40703–9. doi:10.1074/jbc.M202004200. ISSN 0021-9258. PMID 12189133. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading