PRKCB1

PRKCB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I0E
Identifiers
Aliases	PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta, PKCbeta, PKCI(2)
External IDs	OMIM: 176970; MGI: 97596; HomoloGene: 56424; GeneCards: PRKCB; OMA:PRKCB - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	24,220,611 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	122,233,625 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; frontal pole; ; Brodmann area 23; ; Brodmann area 46; ; superior frontal gyrus; ; Brodmann area 10; ; parietal lobe; ; Region I of hippocampus proper; ; postcentral gyrus;
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; primary motor cortex; ; perirhinal cortex; ; Region I of hippocampus proper; ; cingulate gyrus; ; CA3 field; ; superior frontal gyrus; ; visual cortex; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase C activity; histone binding; zinc ion binding; calcium channel regulator activity; chromatin binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; androgen receptor binding; nuclear receptor coactivator activity; histone kinase activity (H3-T6 specific); ATP binding; protein kinase C binding; calcium-dependent protein kinase C activity;
Cellular component	cytoplasm; membrane; plasma membrane; extracellular exosome; nucleus; nucleoplasm; cytosol; calyx of Held; presynaptic cytosol;
Biological process	B cell receptor signaling pathway; cellular response to carbohydrate stimulus; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of B cell receptor signaling pathway; intracellular signal transduction; response to hypoxia; regulation of transcription, DNA-templated; adaptive immune response; phosphorylation; immune system process; regulation of transcription by RNA polymerase II; cellular calcium ion homeostasis; transcription, DNA-templated; positive regulation of angiogenesis; platelet activation; protein phosphorylation; B cell activation; negative regulation of insulin receptor signaling pathway; mitotic nuclear membrane disassembly; negative regulation of glucose transmembrane transport; positive regulation of NF-kappaB transcription factor activity; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; calcium ion transport; signal transduction; lipoprotein transport; apoptotic process; regulation of myeloid cell differentiation; chromatin organization; presynaptic modulation of chemical synaptic transmission; positive regulation of nucleic acid-templated transcription; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5579
	18751
	ENSG00000166501
	ENSMUSG00000052889
	P05771
	P68404
	NM_212535; NM_002738
	NM_008855; NM_001316672
	NP_002729; NP_997700
	NP_001303601; NP_032881
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.^[5]

Template:PBB Summary^[6]

Interactions

PRKCB1 has been shown to interact with RIPK4,^[7] beta adrenergic receptor kinase,^[8] PDLIM5^[9] and GNB2L1.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166501 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052889 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kubo K, Ohno S, Suzuki K (November 1987). "Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II". Nucleic Acids Res. 15 (17): 7179–80. doi:10.1093/nar/15.17.7179. PMC 306204. PMID 3658678.
^ Lintas C; Sacco R; Garbett K; Mirnics K; Militerni R; Bravaccio C; Curatolo P; Manzi B; Schneider C; Melmed R; Elia M; Pascucci T; S Puglisi-Allegra; K-L Reichelt; Persico AM (2009). "Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression". Mol Psychiatry. 14 (7): 705–718. doi:10.1038/mp.2008.21. PMID 18317465.
^ Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Yang, Xing-Long; Zhang Ya-Li; Lai Zhuo-Sheng; Xing Fei-Yue; Liu Yu-Hu (April 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase". World J. Gastroenterol. 9 (4): 800–3. PMID 12679936.
^ Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Ron, D; Jiang Z; Yao L; Vagts A; Diamond I; Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. PMID 10480917.{{cite journal}}: CS1 maint: unflagged free DOI (link)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PRKCB1

Interactions

See also

References

Further reading