PKN3 (gene)

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Protein kinase N3
Identifiers
Symbols PKN3 ; RP11-545E17.1
External IDs OMIM610714 MGI2388285 HomoloGene50980 GeneCards: PKN3 Gene
EC number 2.7.11.13
RNA expression pattern
PBB GE PKN3 gnf1h00136 at tn.png
PBB GE PKN3 gnf1h00137 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 29941 263803
Ensembl ENSG00000160447 ENSMUSG00000026785
UniProt Q6P5Z2 Q8K045
RefSeq (mRNA) NM_013355 NM_153805
RefSeq (protein) NP_037487 NP_722500
Location (UCSC) Chr 9:
131.46 – 131.48 Mb
Chr 2:
30.08 – 30.09 Mb
PubMed search [1] [2]

PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K).[1] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions[edit]

PKN3 (gene) has been shown to interact with ARHGAP26.[2]

References[edit]

  1. ^ "Entrez Gene: PKN3 protein kinase N3". 
  2. ^ Shibata, H; Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (Jul 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". J. Biochem. (Japan) 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. ISSN 0021-924X. PMID 11432776. 

Further reading[edit]