RPS6KB2

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Ribosomal protein S6 kinase, 70kDa, polypeptide 2
Identifiers
Symbols RPS6KB2 ; KLS; P70-beta; P70-beta-1; P70-beta-2; S6K-beta2; S6K2; SRK; STK14B; p70(S6K)-beta; p70S6Kb
External IDs OMIM608939 MGI1927343 HomoloGene68374 ChEMBL: 3111 GeneCards: RPS6KB2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE RPS6KB2 203777 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6199 58988
Ensembl ENSG00000175634 ENSMUSG00000024830
UniProt Q9UBS0 Q9Z1M4
RefSeq (mRNA) NM_001007071 NM_021485
RefSeq (protein) NP_003943 NP_067460
Location (UCSC) Chr 11:
67.2 – 67.2 Mb
Chr 19:
4.16 – 4.16 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.[1][2][3]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.[3]

References[edit]

  1. ^ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun 253 (2): 470–476. doi:10.1006/bbrc.1998.9784. PMID 9878560. 
  2. ^ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J Biol Chem 273 (46): 30061–30064. doi:10.1074/jbc.273.46.30061. PMID 9804755. 
  3. ^ a b "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2". 

Further reading[edit]