IDH3B

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Isocitrate dehydrogenase 3 (NAD+) beta
Identifiers
Symbols IDH3B ; H-IDHB; RP46
External IDs OMIM604526 MGI2158650 HomoloGene5035 GeneCards: IDH3B Gene
EC number 1.1.1.41
RNA expression pattern
PBB GE IDH3B 210418 s at tn.png
PBB GE IDH3B 201509 at tn.png
PBB GE IDH3B 210014 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3420 170718
Ensembl ENSG00000101365 ENSMUSG00000027406
UniProt O43837 Q91VA7
RefSeq (mRNA) NM_001258384 NM_130884
RefSeq (protein) NP_001245313 NP_570954
Location (UCSC) Chr 20:
2.64 – 2.64 Mb
Chr 2:
130.28 – 130.28 Mb
PubMed search [1] [2]

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial is an enzyme that in humans is encoded by the IDH3B gene.[1][2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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TCACycle_WP78 go to article go to article go to article go to article go to HMDB go to article go to article go to article Go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article
|{{{bSize}}}px|alt=TCA Cycle edit|]]
  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

References[edit]

  1. ^ Kim YO, Park SH, Kang YJ, Koh HJ, Kim SH, Park SY, Sohn U, Huh TL (Jan 2000). "Assignment of mitochondrial NAD(+)-specific isocitrate dehydrogenase beta subunit gene (IDH3B) to human chromosome band 20p13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet 86 (3-4): 240–1. doi:10.1159/000015348. PMID 10575215. 
  2. ^ a b "Entrez Gene: IDH3B isocitrate dehydrogenase 3 (NAD+) beta". 

Further reading[edit]

External links[edit]