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Sterile alpha motif and leucine zipper containing kinase AZK
Symbols ZAK ; AZK; MLK7; MLT; MLTK; MRK; mlklak; pk
External IDs OMIM609479 MGI2443258 HomoloGene32331 ChEMBL: 3886 GeneCards: ZAK Gene
EC number
RNA expression pattern
PBB GE ZAK 218833 at tn.png
More reference expression data
Species Human Mouse
Entrez 51776 65964
Ensembl ENSG00000091436 ENSMUSG00000004085
UniProt Q9NYL2 Q9ESL4
RefSeq (mRNA) NM_016653 NM_001164791
RefSeq (protein) NP_057737 NP_001158263
Location (UCSC) Chr 2:
173.94 – 174.13 Mb
Chr 2:
72.29 – 72.44 Mb
PubMed search [1] [2]

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[1]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]


ZAK has been shown to interact with ZNF33A.[2]


  1. ^ a b "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK". 
  2. ^ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. (United States) 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642. 

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