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MAP kinase interacting serine/threonine kinase 2
Protein MKNK2 PDB 2ac3.png
PDB rendering based on 2ac3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MKNK2 ; GPRK7; MNK2
External IDs OMIM605069 MGI894279 HomoloGene49674 ChEMBL: 4204 GeneCards: MKNK2 Gene
EC number
RNA expression pattern
PBB GE MKNK2 218205 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2872 17347
Ensembl ENSG00000099875 ENSMUSG00000020190
UniProt Q9HBH9 Q8CDB0
RefSeq (mRNA) NM_017572 NM_021462
RefSeq (protein) NP_060042 NP_067437
Location (UCSC) Chr 19:
2.04 – 2.05 Mb
Chr 10:
80.67 – 80.67 Mb
PubMed search [1] [2]

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[1][2]


MKNK2 has been shown to interact with MAPK1[3][4] and Eukaryotic translation initiation factor 4 gamma.[3]


  1. ^ Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (Oct 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076. 
  2. ^ "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2". 
  3. ^ a b Scheper, Gert C; Parra Josep L; Wilson Mary; Van Kollenburg Barbara; Vertegaal Alfred C O; Han Ze-Guang; Proud Christopher G (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. (United States) 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. ISSN 0270-7306. PMC 166352. PMID 12897141. 
  4. ^ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. (ENGLAND) 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017. 

Further reading[edit]