IDH2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Isocitrate dehydrogenase 2 (NADP+), mitochondrial
Protein IDH2 PDB 1lwd.png
PDB rendering based on 1lwd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IDH2 ; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH
External IDs OMIM147650 MGI96414 HomoloGene37590 GeneCards: IDH2 Gene
EC number 1.1.1.42
RNA expression pattern
PBB GE IDH2 210046 s at tn.png
PBB GE IDH2 210045 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3418 269951
Ensembl ENSG00000182054 ENSMUSG00000030541
UniProt P48735 P54071
RefSeq (mRNA) NM_001289910 NM_173011
RefSeq (protein) NP_001276839 NP_766599
Location (UCSC) Chr 15:
90.63 – 90.65 Mb
Chr 7:
80.09 – 80.12 Mb
PubMed search [1] [2]

Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.[1]

Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.[1] Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
TCACycle_WP78 go to article go to article go to article go to article go to HMDB go to article go to article go to article Go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
TCACycle_WP78 go to article go to article go to article go to article go to HMDB go to article go to article go to article Go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article
|{{{bSize}}}px|alt=TCA Cycle edit|]]
  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 

References[edit]

  1. ^ a b "Entrez Gene: IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial". 
  2. ^ Amary, MF; Damato, S, Halai, D, Eskandarpour, M, Berisha, F, Bonar, F, McCarthy, S, Fantin, VR, Straley, KS, Lobo, S, Aston, W, Green, CL, Gale, RE, Tirabosco, R, Futreal, A, Campbell, P, Presneau, N, Flanagan, AM (Nov 6, 2011). "Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.". Nature Genetics 43 (12): 1262–5. doi:10.1038/ng.994. PMID 22057236. 

Further reading[edit]

  • Bruns GA, Eisenman RE, Gerald PS (1977). "Human mitochondrial NADP-dependent isocitrate dehydrogenase in man-mouse somatic cell hybrids.". Cytogenet. Cell Genet. 17 (4): 200–11. doi:10.1159/000130713. PMID 11969. 
  • Shimizu N, Giles RE, Kucherlapati RS et al. (1978). "Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of chromosome 15.". Somatic Cell Genet. 3 (1): 47–60. doi:10.1007/BF01550986. PMID 564083. 
  • Champion MJ, Brown JA, Shows TB (1979). "Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man.". Cytogenet. Cell Genet. 22 (1-6): 498–502. doi:10.1159/000131007. PMID 752528. 
  • Grzeschik KH (1976). "Assignment of a gene for human mitochondrial isocitrate dehydrogenase (ICD-M, EC 1.1.1.41) to chromosome 15.". Hum. Genet. 34 (1): 23–8. doi:10.1007/BF00284430. PMID 965003. 
  • Klimek J, Boguslawski W, Tialowska B, Zelewski L (1976). "Regulation of progesterone biosynthesis in human placental mitochondria by Krebs cycle metabolites.". Acta Biochim. Pol. 23 (2-3): 185–92. PMID 970033. 
  • Chamberlain KG, Penington DG (1988). "Monoamine oxidase and other mitochondrial enzymes in density subpopulations of human platelets.". Thromb. Haemost. 59 (1): 29–33. PMID 3363531. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Luo H, Shan X, Wu J (1996). "Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation". J. Cell. Biochem. 60 (4): 495–507. doi:10.1002/(SICI)1097-4644(19960315)60:4<495::AID-JCB6>3.0.CO;2-N. PMID 8707889. 
  • Oh IU, Inazawa J, Kim YO et al. (1997). "Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization.". Genomics 38 (1): 104–6. doi:10.1006/geno.1996.0602. PMID 8954790. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Foster LJ, Rudich A, Talior I et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496. 
  • Kil IS, Kim SY, Lee SJ, Park JW (2007). "Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs.". Free Radic. Biol. Med. 43 (8): 1197–207. doi:10.1016/j.freeradbiomed.2007.07.009. PMID 17854715.