PRKCI

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Protein kinase C, iota
Protein PRKCI PDB 1vd2.png
PDB rendering based on 1vd2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRKCI ; DXS1179E; PKCI; nPKC-iota
External IDs OMIM600539 MGI99260 HomoloGene37667 ChEMBL: 2598 GeneCards: PRKCI Gene
EC number 2.7.11.13
RNA expression pattern
PBB GE PRKCI 209678 s at tn.png
PBB GE PRKCI 209677 at tn.png
PBB GE PRKCI 213518 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5584 18759
Ensembl ENSG00000163558 ENSMUSG00000037643
UniProt P41743 Q62074
RefSeq (mRNA) NM_002740 NM_008857
RefSeq (protein) NP_002731 NP_032883
Location (UCSC) Chr 3:
169.94 – 170.02 Mb
Chr 3:
31 – 31.05 Mb
PubMed search [1] [2]

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.[1][2][3]

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.[3]

Interactions[edit]

PRKCI has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase,[4] Centaurin, alpha 1,[5] Phosphoinositide-dependent kinase-1,[6] FRS2,[7] SMG1 (gene),[8] Sequestosome 1 and PARD3.[9][10]

References[edit]

  1. ^ Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (August 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics 26 (3): 629–31. doi:10.1016/0888-7543(95)80190-W. PMID 7607695. 
  2. ^ De Donato M, Gallagher DS Jr, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenet Cell Genet 95 (1–2): 79–81. doi:10.1159/000057021. PMID 11978974. 
  3. ^ a b "Entrez Gene: PRKCI protein kinase C, iota". 
  4. ^ Tisdale EJ (February 2002). "Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway". The Journal of Biological Chemistry 277 (5): 3334–41. doi:10.1074/jbc.M109744200. PMID 11724794. 
  5. ^ Zemlickova E, Dubois T, Kerai P, et al. (August 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. doi:10.1016/S0006-291X(03)01187-2. PMID 12893243. 
  6. ^ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". The Journal of Biological Chemistry 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742. 
  7. ^ Lim YP, Low BC, Lim J, Wong ES, Guy GR (July 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". The Journal of Biological Chemistry 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. PMID 10383403. 
  8. ^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (1 January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology 16 (1): 105–14. PMC 230983. PMID 8524286. 
  9. ^ Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1 May 1998). "Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62". Molecular and Cellular Biology 18 (5): 3069–80. PMC 110686. PMID 9566925. 
  10. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (December 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochemical and Biophysical Research Communications 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187. 

Further reading[edit]