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Mitogen-activated protein kinase 4
Symbols MAPK4 ; ERK-4; ERK4; PRKM4; p63-MAPK; p63MAPK
External IDs OMIM176949 MGI2444559 HomoloGene2058 IUPHAR: 2091 ChEMBL: 5759 GeneCards: MAPK4 Gene
EC number
RNA expression pattern
PBB GE MAPK4 204707 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5596 225724
Ensembl ENSG00000141639 ENSMUSG00000024558
UniProt P31152 Q6P5G0
RefSeq (mRNA) NM_001292039 NM_172632
RefSeq (protein) NP_001278968 NP_766220
Location (UCSC) Chr 18:
48.09 – 48.26 Mb
Chr 18:
73.93 – 74.07 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[1][2]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[2]

The Arabidopsis MAPK4 is important in signalling [3]


  1. ^ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene 9 (2): 647–9. PMID 8290275. 
  2. ^ a b "Entrez Gene: MAPK4 mitogen-activated protein kinase 4". 
  3. ^ Petersen, M. Brodersen, P. Naested, H. Andreasson, E. Lindhart, U. Johansen, B. Nielsen, M. B. Lacy, M., Austin, M. J. Parker, J. E. Sharma, S. B. Klessig, D. F.. Martienssen, R. Mattsson, O. Jensen, A. B. and Mundy, J. Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance. (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186. 

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