AKT2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
V-akt murine thymoma viral oncogene homolog 2
Protein AKT2 PDB 1gzk.png
PDB rendering based on 1gzk.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AKT2 ; HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA
External IDs OMIM164731 MGI104874 HomoloGene48773 ChEMBL: 2431 GeneCards: AKT2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE AKT2 203809 s at tn.png
PBB GE AKT2 211453 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 208 11652
Ensembl ENSG00000105221 ENSMUSG00000004056
UniProt P31751 Q60823
RefSeq (mRNA) NM_001243027 NM_001110208
RefSeq (protein) NP_001229956 NP_001103678
Location (UCSC) Chr 19:
40.74 – 40.79 Mb
Chr 7:
27.59 – 27.64 Mb
PubMed search [1] [2]

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.[1]

Function[edit]

This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.[2]

Clinical significance[edit]

The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.[2]

Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initaited by the large T antigen as well as the neu oncogene.[3]

Interactions[edit]

AKT2 has been shown to interact with:

References[edit]

  1. ^ Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR (November 1992). "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas". Proc Natl Acad Sci U S A 89 (19): 9267–71. doi:10.1073/pnas.89.19.9267. PMC 50107. PMID 1409633. 
  2. ^ a b "Entrez Gene: AKT2 v-akt murine thymoma viral oncogene homolog 2". 
  3. ^ Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ (2011). "Akt1 and Akt2: differentiating the aktion". Histol. Histopathol. 26 (5): 651–62. PMID 21432781. 
  4. ^ Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR (September 1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2". Oncogene 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823. 
  5. ^ Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ (August 2002). "Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells". J. Biol. Chem. 277 (33): 29973–82. doi:10.1074/jbc.M203636200. PMID 12048203. 
  6. ^ Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284. 
  7. ^ Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444. 
  8. ^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986. 


Further reading[edit]