BRSK2
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| BR serine/threonine kinase 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | BRSK2; C11orf7; PEN11B; SAD1; STK29 | ||||||||||
| External IDs | OMIM: 609236 MGI: 1923020 HomoloGene: 123829 GeneCards: BRSK2 Gene | ||||||||||
| EC number | [u'2.7.11.1', u'2.7.11.26' [u'2.7.11.1', u'2.7.11.26']] | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 9024 | 75770 | |||||||||
| Ensembl | ENSG00000174672 | ENSMUSG00000053046 | |||||||||
| UniProt | Q8IWQ3 | Q69Z98 | |||||||||
| RefSeq (mRNA) | NM_003957.2 | NM_001009929.2 | |||||||||
| RefSeq (protein) | NP_003948.2 | NP_001009929.1 | |||||||||
| Location (UCSC) | Chr 11: 1.41 – 1.48 Mb |
Chr 7: 149.14 – 149.19 Mb |
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| PubMed search | [1] | [2] | |||||||||
BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.[1][2][3]
[edit] References
- ^ Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". J Hum Genet 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.
- ^ Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". J Hum Genet 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.
- ^ "Entrez Gene: BRSK2 BR serine/threonine kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9024.
[edit] Further reading
- Stanchi F, Bertocco E, Toppo S et al (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lizcano JM, Göransson O, Toth R et al (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=381014.
- Lu R, Niida H, Nakanishi M (2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". J. Biol. Chem. 279 (30): 31164–70. doi:10.1074/jbc.M404728200. PMID 15150265.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Sabater L, Gómez-Choco M, Saiz A, Graus F (2006). "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis". J. Neuroimmunol. 170 (1–2): 186–90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222.
- Inoue E, Mochida S, Takagi H et al (2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron 50 (2): 261–75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837.
- Guo Z, Tang W, Yuan J et al (2006). "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochem. Biophys. Res. Commun. 347 (4): 867–71. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.
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