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Ribosomal protein S6 kinase, 90kDa, polypeptide 4
Symbols RPS6KA4 ; MSK2; RSK-B
External IDs OMIM603606 MGI1930076 HomoloGene69288 ChEMBL: 3125 GeneCards: RPS6KA4 Gene
EC number
RNA expression pattern
PBB GE RPS6KA4 204632 at tn.png
More reference expression data
Species Human Mouse
Entrez 8986 56613
Ensembl ENSG00000162302 ENSMUSG00000024952
UniProt O75676 Q9Z2B9
RefSeq (mRNA) NM_001006944 NM_019924
RefSeq (protein) NP_001006945 NP_064308
Location (UCSC) Chr 11:
64.13 – 64.14 Mb
Chr 19:
6.83 – 6.84 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[1][2][3]


This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]


RPS6KA4 has been shown to interact with MAPK14.[1]


  1. ^ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677. 
  2. ^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510. 
  3. ^ a b "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4". 

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