Tropomyosin kinase

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tropomyosin kinase
Identifiers
EC number 2.7.11.28
CAS number 90804-56-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a tropomyosin kinase (EC 2.7.11.28) is an enzyme that catalyzes the chemical reaction

ATP + tropomyosin \rightleftharpoons ADP + O-phosphotropomyosin

Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.

References[edit]

  • deBelle I, Mak AS (1987). "Isolation and characterization of tropomyosin kinase from chicken embryo". Biochim. Biophys. Acta. 925 (1): 17–26. doi:10.1016/0304-4165(87)90143-7. PMID 3593768. 
  • Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259 (9): 5555–60. PMID 6325440. 
  • Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues". Biochemistry. 27 (12): 4506–12. doi:10.1021/bi00412a043. PMID 3166994.