IRAK3

IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459 MGI: 1921164 HomoloGene: 36215 GeneCards: IRAK3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	66,254,622 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	120,038,035 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow; ; parietal pleura; ; blood; ; right lung; ; bone marrow cells; ; palpebral conjunctiva; ; spleen; ; lower lobe of lung; ; trabecular bone;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; bone marrow; ; ankle; ; sciatic nerve; ; lip; ; blood; ; stria vascularis; ; mammary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; transferase activity; magnesium ion binding; protein serine/threonine kinase activity; kinase activity; protein homodimerization activity; protein heterodimerization activity; ATP binding; protein binding;
Cellular component	cytoplasm; nucleus; plasma membrane;
Biological process	response to lipopolysaccharide; negative regulation of innate immune response; signal transduction; negative regulation of macrophage cytokine production; protein autophosphorylation; negative regulation of protein-containing complex disassembly; response to interleukin-1; response to exogenous dsRNA; protein phosphorylation; negative regulation of toll-like receptor signaling pathway; cytokine-mediated signaling pathway; response to virus; response to peptidoglycan; negative regulation of cytokine-mediated signaling pathway; regulation of protein-containing complex disassembly; positive regulation of macrophage tolerance induction; negative regulation of NF-kappaB transcription factor activity; phosphorylation; negative regulation of protein catabolic process; negative regulation of interleukin-6 production; interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; negative regulation of MAP kinase activity; negative regulation of tumor necrosis factor production; negative regulation of interleukin-12 production; MyD88-dependent toll-like receptor signaling pathway; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11213
	73914
	ENSG00000090376
	ENSMUSG00000020227
	Q9Y616
	Q8K4B2
	NM_007199; NM_001142523
	NM_028679; NM_001359184
	NP_001135995; NP_009130
	NP_082955; NP_001346113
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J Biol Chem. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading