TRPV2

TRPV2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F37
Identifiers
Aliases	TRPV2, VRL, VRL-1, VRL1, transient receptor potential cation channel subfamily V member 2
External IDs	OMIM: 606676; MGI: 1341836; HomoloGene: 7993; GeneCards: TRPV2; OMA:TRPV2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	16,437,003 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,491,341 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; upper lobe of left lung; ; spleen; ; blood; ; right coronary artery; ; right lung; ; monocyte; ; right adrenal gland; ; right adrenal cortex; ; left coronary artery;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; facial motor nucleus; ; thymus; ; stroma of bone marrow; ; mesenteric lymph nodes; ; blood; ; spleen; ; calvaria; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion transmembrane transporter activity; ion channel activity; cation channel activity; calcium channel activity;
Cellular component	cytoplasm; integral component of membrane; cell body; membrane; melanosome; plasma membrane; growth cone membrane; axonal growth cone; integral component of plasma membrane; intracellular anatomical structure; cell surface; axon;
Biological process	sensory perception; response to heat; ion transport; positive regulation of calcium ion import; calcium ion transmembrane transport; positive regulation of axon extension; response to temperature stimulus; calcium ion transport; transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51393
	22368
	ENSG00000187688
	ENSMUSG00000018507
	Q9Y5S1
	Q9WTR1
	NM_016113
	NM_011706; NM_001382489; NM_001382490; NM_001382491; NM_001382492
	NP_057197
	NP_035836; NP_001369418; NP_001369419; NP_001369420; NP_001369421
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene.^[5]^[6]

Function

This gene encodes an ion channel that is activated by high temperatures above 52 °C. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.^[7]

History

TRPV2 was independently discovered by two research groups and described in 1999. It was identified in the lab of David Julius as a close homolog of TRPV1, the first identified thermosensitive ion channel.^[5] The group of Itaru Kojima from Gunma University was looking for a protein which is responsible for the entry of calcium into cells in response to insulin-like growth factor-1 (IGF-1). Upon stimulation of cells with IGF-1 TRPV2 translocates towards and integrates into the cell membrane and increases intracellular calcium concentrations.^[8]

Activators and inhibitors

TRPV2 is activated by high temperatures above 52 °C. Alternatively it can be activated at lower temperatures by chemicals, such as the research tool 2-APB,^[9] the plant cannabinoid cannabidiol,^[10] and probenecid.^[11] It is blocked by ruthenium red and lanthanum.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187688 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018507 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (Apr 1999). "A capsaicin-receptor homologue with a high threshold for noxious heat". Nature. 398 (6726): 436–41. doi:10.1038/18906. PMID 10201375.
^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
^ "Entrez Gene: TRPV2 transient receptor potential cation channel, subfamily V, member 2".
^ ^a ^b Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (July 1999). "Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I". Nat. Cell Biol. 1 (3): 165–70. doi:10.1038/11086. PMID 10559903.
^ Hu HZ, Gu Q, Wang C, et al. (August 2004). "2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3". J. Biol. Chem. 279 (34): 35741–8. doi:10.1074/jbc.M404164200. PMID 15194687.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (June 2008). "TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons". J. Neurosci. 28 (24): 6231–8. doi:10.1523/JNEUROSCI.0504-08.2008. PMID 18550765.
^ Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (September 2007). "Transient receptor potential V2 expressed in sensory neurons is activated by probenecid". Neurosci. Lett. 425 (2): 120–5. doi:10.1016/j.neulet.2007.08.035. PMID 17850966.

External links

TRPV2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187688 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018507 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10201375-5] Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (Apr 1999). "A capsaicin-receptor homologue with a high threshold for noxious heat". Nature. 398 (6726): 436–41. doi:10.1038/18906. PMID 10201375.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

[7] "Entrez Gene: TRPV2 transient receptor potential cation channel, subfamily V, member 2".

[pmid10559903-8] Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (July 1999). "Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I". Nat. Cell Biol. 1 (3): 165–70. doi:10.1038/11086. PMID 10559903.

[pmid15194687-9] Hu HZ, Gu Q, Wang C, et al. (August 2004). "2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3". J. Biol. Chem. 279 (34): 35741–8. doi:10.1074/jbc.M404164200. PMID 15194687.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid18550765-10] Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (June 2008). "TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons". J. Neurosci. 28 (24): 6231–8. doi:10.1523/JNEUROSCI.0504-08.2008. PMID 18550765.

[pmid17850966-11] Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (September 2007). "Transient receptor potential V2 expressed in sensory neurons is activated by probenecid". Neurosci. Lett. 425 (2): 120–5. doi:10.1016/j.neulet.2007.08.035. PMID 17850966.

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