CAMK1

CAMK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4FG7, 4FG8, 4FG9, 4FGB
Identifiers
Aliases	CAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDs	OMIM: 604998 MGI: 1098535 HomoloGene: 117458 GeneCards: CAMK1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	9,769,992 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,320,945 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; prefrontal cortex; ; caudate nucleus; ; monocyte; ; amygdala; ; left uterine tube; ; putamen; ; cingulate gyrus; ; left coronary artery; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; external carotid artery; ; dorsomedial hypothalamic nucleus; ; internal carotid artery; ; arcuate nucleus; ; myocardium of ventricle; ; ventromedial nucleus; ; calvaria; ; lateral hypothalamus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; catalytic activity; ATP binding; calmodulin-dependent protein kinase activity; calmodulin binding;
Cellular component	cytoplasm; nucleus; intracellular anatomical structure; postsynaptic density; glutamatergic synapse; cytosol;
Biological process	cell differentiation; positive regulation of synapse structural plasticity; positive regulation of muscle cell differentiation; regulation of muscle cell differentiation; phosphorylation; positive regulation of syncytium formation by plasma membrane fusion; regulation of histone H3-K9 acetylation; negative regulation of protein binding; positive regulation of dendritic spine development; nervous system development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of protein acetylation; regulation of protein localization; positive regulation of protein export from nucleus; multicellular organism development; protein phosphorylation; nucleocytoplasmic transport; positive regulation of neuron projection development; cell cycle; metabolism; regulation of protein binding; positive regulation of transcription by RNA polymerase II; signal transduction; peptidyl-threonine phosphorylation; intracellular signal transduction; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	8536
	52163
	ENSG00000134072
	ENSMUSG00000030272
	Q14012
	Q91YS8
	NM_003656
	NM_133926
	NP_003647; NP_003647.1
	NP_598687
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134072 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030272 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading