MELK

MELK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BKY, 4BKZ, 4D2P, 4D2T, 4D2V, 4D2W, 4IXP, 4UMP, 4UMQ, 4UMR, 4UMT, 4UMU, 5IHA, 5IHC, 5IH9, 5IH8
Identifiers
Aliases	MELK, HPK38, maternal embryonic leucine zipper kinase
External IDs	OMIM: 607025 MGI: 106924 HomoloGene: 32111 GeneCards: MELK
EC number	2.7.10.2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	36,677,683 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	44,364,675 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; embryo; ; ganglionic eminence; ; amniotic fluid; ; tibia; ; trabecular bone; ; bone marrow; ; oral cavity; ; stromal cell of endometrium; ; rectum;
	Top expressed in
	primitive streak; ; abdominal wall; ; dermis; ; ureter; ; endocardial cushion; ; maxillary prominence; ; medial ganglionic eminence; ; right lobe of liver; ; somite; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; lipid binding;
Cellular component	cytoplasm; membrane; plasma membrane; cell cortex; nucleus;
Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress; hemopoiesis; intracellular signal transduction; phosphorylation; protein phosphorylation; G2/M transition of mitotic cell cycle; neural precursor cell proliferation; positive regulation of apoptotic process; protein autophosphorylation; cell cycle; cell population proliferation; apoptotic process; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9833
	17279
	ENSG00000165304
	ENSMUSG00000035683
	Q14680
	Q61846
NM_001256685; NM_001256687; NM_001256688; NM_001256689; NM_001256690;
	NM_001256691; NM_001256692; NM_001256693; NM_014791
	NM_010790
NP_001243614; NP_001243616; NP_001243617; NP_001243618; NP_001243619;
	NP_001243620; NP_001243621; NP_001243622; NP_055606
	NP_034920
	Wikidata
View/Edit Human	View/Edit Mouse

Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.^[5]^[6]^[7]

Interactions

MELK has been shown to interact with CDC25B.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035683 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
^ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.

Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384. PMID 17280616.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beullens M, Vancauwenbergh S, Morrice N, Derua R, Ceulemans H, Waelkens E, Bollen M (2006). "Substrate specificity and activity regulation of protein kinase MELK". J. Biol. Chem. 280 (48): 40003–11. doi:10.1074/jbc.M507274200. PMID 16216881.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Vulsteke V, Beullens M, Boudrez A, Keppens S, Van Eynde A, Rider MH, Stalmans W, Bollen M (2004). "Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1". J. Biol. Chem. 279 (10): 8642–7. doi:10.1074/jbc.M311466200. PMID 14699119.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.
Seong HA, Gil M, Kim KT, Kim SJ, Ha H (2002). "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)". Biochem. J. 361 (Pt 3): 597–604. doi:10.1042/0264-6021:3610597. PMC 1222342. PMID 11802789.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gil M, Yang Y, Lee Y, Choi I, Ha H (1997). "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells". Gene. 195 (2): 295–301. doi:10.1016/S0378-1119(97)00181-9. PMID 9305775.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035683 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8724849-5] Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.

[pmid9136115-6] Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.

[entrez-7] "Entrez Gene: MELK maternal embryonic leucine zipper kinase".

[pmid12400006-8] Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading