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2-MDP

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2-MDP
Identifiers
  • 3-amino-2-methyl-1,1-di(phenyl)propan-1-ol
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H19NO
Molar mass241.334 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)(c2ccccc2)C(C)CN
  • InChI=1S/C16H19NO/c1-13(12-17)16(18,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,13,18H,12,17H2,1H3 checkY
  • Key:XGYCHIPEPHYUIH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The levo or (-) isomer is the active form of the drug.[1][2] It also has stimulant effects, having only around one third the potency of amphetamine by weight, but with a long duration of action, lasting more than 24 hours from a single oral dose.[3]

References

  1. ^ Tang AH, Cangelosi AA, Code RA, Franklin SR. Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP). Pharmacology Biochemistry and Behavior. 1984 Feb;20(2):209-13.
  2. ^ Blake JC, Davies SN, Church J, Martin D, Lodge D. 2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA). Pharmacology Biochemistry and Behavior. 1986 Jan;24(1):23-5.
  3. ^ John H Biel. Annual Reports in Medicinal Chemistry, Volume 2. Academic Press 1966. p18.


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