Pheniramine

Pheniramine

Clinical data
Pregnancy category	A
Routes of administration	Oral
ATC code	R06AB05 (WHO)
Pharmacokinetic data
Metabolism	Hepatic hydroxylation, demethylation and glucuronidation
Excretion	Renal
Identifiers
IUPAC name N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
CAS Number	86-21-5
PubChem CID	4761
ChemSpider	4597 Y
UNII	134FM9ZZ6M
KEGG	D08355 Y
ChEMBL	ChEMBL1193 Y
CompTox Dashboard (EPA)	DTXSID0023454
ECHA InfoCard	100.001.506
Chemical and physical data
Formula	C16H20N2
Molar mass	240.343 g/mol g·mol−1
3D model (JSmol)	Interactive image
SMILES n1ccccc1C(c2ccccc2)CCN(C)C
InChI InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3 Y Key:IJHNSHDBIRRJRN-UHFFFAOYSA-N Y
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Pheniramine (Avil) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.

Chemical relatives

Derivatives of pheniramine include chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, deschlorpheniramine, triprolidine, and brompheniramine. Two other halogenated derivatives, iodopheniramine and fluorpheniramine, are currently in use for research on combination therapies for malaria and some cancers. The halogenation of pheniramine increases its potency by 20-fold.

Side effects

Avil may cause drowsiness, and over-dosage may lead to sleep disorders. Overdose may lead to seizures, especially in combination with alcohol. Those with cartisol for long term should avoid avil as it may cause loss of adreline which may lead to losing consciousness.

External links

• Leaflet on Avil by The Royal Australian College of General Practitioners