Bremazocine

Bremazocine
Clinical data
Routes of; administration	Oral
ATC code	none;
Identifiers
	IUPAC name 6-ethyl- 3-[(1-hydroxycyclopropyl)methyl]- 11,11-dimethyl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin-8- ol; or; 2-(1-hydroxy- cyclopropylmethyl)- 5-ethyl- 9,9-dimethyl- 2'-hydroxy- 6,7-benzomorphan;
CAS Number	75684-07-0;
PubChem CID	1223;
IUPHAR/BPS	1603;
ChemSpider	1186;
UNII	ISF76M2DBE;
ChEMBL	ChEMBL1165792 ;
Chemical and physical data
Formula	C20H29NO2
Molar mass	315.45 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1(CC1)CN4[C@@H]3Cc2c(cc(O)cc2)[C@@](C3(C)C)(CC4)CC;

Bremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects.^[1] It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing.^[2]

References

^ Dortch-Carnes J, Potter DE (2005). "Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties". CNS Drug Reviews. 11 (2): 195–212. doi:10.1111/j.1527-3458.2005.tb00270.x. PMID 16007240.
^ Patrick, Graham (2013). An Introduction to Medicinal Chemistry (5th expanded ed.). Oxford University Press. p. 641. ISBN 0199697396.

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