Protease-activated receptor 2: Difference between revisions

F2RL1
Identifiers
Aliases	F2RL1, GPR11, PAR2, Protease activated receptor 2, F2R like trypsin receptor 1
External IDs	OMIM: 600933; MGI: 101910; HomoloGene: 21087; GeneCards: F2RL1; OMA:F2RL1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	76,835,315 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,661,735 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; kidney tubule; ; rectum; ; islet of Langerhans; ; nipple; ; caput epididymis; ; seminal vesicula; ; human penis; ; vulva;
	Top expressed in
	epithelium of stomach; ; left colon; ; pineal gland; ; ileum; ; corneal stroma; ; mucous cell of stomach; ; pyloric antrum; ; jejunum; ; lip; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; thrombin-activated receptor activity; G-protein beta-subunit binding; protein binding; G-protein alpha-subunit binding; signaling receptor binding; signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; pseudopodium; membrane; plasma membrane; integral component of plasma membrane; early endosome;
Biological process	positive regulation of Rho protein signal transduction; establishment of endothelial barrier; thrombin-activated receptor signaling pathway; neutrophil activation; positive regulation of phagocytosis, engulfment; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of eosinophil degranulation; positive regulation of neutrophil mediated killing of gram-negative bacterium; negative regulation of tumor necrosis factor-mediated signaling pathway; immune system process; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; blood coagulation; positive regulation of JNK cascade; positive regulation of leukocyte chemotaxis; negative regulation of JNK cascade; leukocyte proliferation; regulation of JNK cascade; positive regulation of pseudopodium assembly; positive regulation of renin secretion into blood stream; defense response to virus; positive regulation of chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of superoxide anion generation; positive regulation of glomerular filtration; regulation of blood coagulation; inflammatory response; innate immune response; mature conventional dendritic cell differentiation; negative regulation of toll-like receptor 3 signaling pathway; positive regulation of actin filament depolymerization; leukocyte migration; regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; positive regulation of positive chemotaxis; signal transduction; T cell activation involved in immune response; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell-cell junction maintenance;
	Sources:Amigo / QuickGO
Orthologs
	2150
	14063
	ENSG00000164251
	ENSMUSG00000021678
	P55085
	P55086
	NM_005242
	NM_007974
	NP_005233
	NP_032000
	Wikidata
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Revision as of 23:33, 24 November 2007

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Coagulation factor II (thrombin) receptor-like 1, also known as F2RL1 or protease activated receptor 2 (PAR2), is a human gene.

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164251 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021678 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

@@ Line 66: / Line 66: @@
 *{{cite journal  | author=Kawabata A |title=PAR-2: structure, function and relevance to human diseases of the gastric mucosa. |journal=Expert reviews in molecular medicine |volume=4 |issue= 16 |pages= 1-17 |year= 2004 |pmid= 14585156 |doi= doi:10.1017/S1462399402004799 }}
 *{{cite journal  | author=Bushell T |title=The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. |journal=J. Physiol. (Lond.) |volume=581 |issue= Pt 1 |pages= 7-16 |year= 2007 |pmid= 17347265 |doi= 10.1113/jphysiol.2007.129577 }}
+*{{cite journal  | author=Nystedt S, Emilsson K, Larsson AK, ''et al.'' |title=Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. |journal=Eur. J. Biochem. |volume=232 |issue= 1 |pages= 84-9 |year= 1995 |pmid= 7556175 |doi=  }}
+*{{cite journal  | author=Santulli RJ, Derian CK, Darrow AL, ''et al.'' |title=Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 20 |pages= 9151-5 |year= 1995 |pmid= 7568091 |doi=  }}
+*{{cite journal  | author=Nystedt S, Emilsson K, Wahlestedt C, Sundelin J |title=Molecular cloning of a potential proteinase activated receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 20 |pages= 9208-12 |year= 1994 |pmid= 7937743 |doi=  }}
+*{{cite journal  | author=Mirza H, Yatsula V, Bahou WF |title=The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. |journal=J. Clin. Invest. |volume=97 |issue= 7 |pages= 1705-14 |year= 1996 |pmid= 8601636 |doi=  }}
+*{{cite journal  | author=Bohm SK, Kong W, Bromme D, ''et al.'' |title=Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. |journal=Biochem. J. |volume=314 ( Pt 3) |issue=  |pages= 1009-16 |year= 1996 |pmid= 8615752 |doi=  }}
+*{{cite journal  | author=Böhm SK, Khitin LM, Grady EF, ''et al.'' |title=Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22003-16 |year= 1996 |pmid= 8703006 |doi=  }}
+*{{cite journal  | author=Kahn M, Ishii K, Kuo WL, ''et al.'' |title=Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. |journal=Mol. Med. |volume=2 |issue= 3 |pages= 349-57 |year= 1996 |pmid= 8784787 |doi=  }}
+*{{cite journal  | author=Molino M, Barnathan ES, Numerof R, ''et al.'' |title=Interactions of mast cell tryptase with thrombin receptors and PAR-2. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4043-9 |year= 1997 |pmid= 9020112 |doi=  }}
+*{{cite journal  | author=Howells GL, Macey MG, Chinni C, ''et al.'' |title=Proteinase-activated receptor-2: expression by human neutrophils. |journal=J. Cell. Sci. |volume=110 ( Pt 7) |issue=  |pages= 881-7 |year= 1997 |pmid= 9133675 |doi=  }}
+*{{cite journal  | author=D'Andrea MR, Derian CK, Leturcq D, ''et al.'' |title=Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. |journal=J. Histochem. Cytochem. |volume=46 |issue= 2 |pages= 157-64 |year= 1998 |pmid= 9446822 |doi=  }}
+*{{cite journal  | author=Guyonnet Dupérat V, Jacquelin B, Boisseau P, ''et al.'' |title=Protease-activated receptor genes are clustered on 5q13. |journal=Blood |volume=92 |issue= 1 |pages= 25-31 |year= 1998 |pmid= 9639495 |doi=  }}
+*{{cite journal  | author=Steinhoff M, Corvera CU, Thoma MS, ''et al.'' |title=Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. |journal=Exp. Dermatol. |volume=8 |issue= 4 |pages= 282-94 |year= 1999 |pmid= 10439226 |doi=  }}
+*{{cite journal  | author=Takeuchi T, Harris JL, Huang W, ''et al.'' |title=Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26333-42 |year= 2000 |pmid= 10831593 |doi= 10.1074/jbc.M002941200 }}
+*{{cite journal  | author=Loew D, Perrault C, Morales M, ''et al.'' |title=Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. |journal=Biochemistry |volume=39 |issue= 35 |pages= 10812-22 |year= 2000 |pmid= 10978167 |doi=  }}
+*{{cite journal  | author=Knight DA, Lim S, Scaffidi AK, ''et al.'' |title=Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. |journal=J. Allergy Clin. Immunol. |volume=108 |issue= 5 |pages= 797-803 |year= 2001 |pmid= 11692107 |doi= 10.1067/mai.2001.119025 }}
+*{{cite journal  | author=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615-22 |year= 2002 |pmid= 11714832 |doi=  }}
+*{{cite journal  | author=Asokananthan N, Graham PT, Fink J, ''et al.'' |title=Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3577-85 |year= 2002 |pmid= 11907122 |doi=  }}
 }}
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Protease-activated receptor 2: Difference between revisions

Revision as of 23:33, 24 November 2007

See also

References

Further reading