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Egf-like module containing, mucin-like, hormone receptor-like 1
Symbols EMR1 ; TM7LN3
External IDs OMIM600493 MGI106912 HomoloGene1493 IUPHAR: EMR1 GeneCards: EMR1 Gene
RNA expression pattern
PBB GE EMR1 207111 at tn.png
More reference expression data
Species Human Mouse
Entrez 2015 13733
Ensembl ENSG00000174837 ENSMUSG00000004730
UniProt Q14246 Q61549
RefSeq (mRNA) NM_001256252 NM_010130
RefSeq (protein) NP_001243181 NP_034260
Location (UCSC) Chr 19:
6.89 – 6.94 Mb
Chr 17:
57.36 – 57.48 Mb
PubMed search [1] [2]

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3] The mouse homologue is known as F4/80.[4]


This gene encodes a protein that is a member of the adhesion-GPCR family. [5] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 region via membrane proximal GAIN domain. In the case of EMR1 these domains are Epidermal Growth Factor (EGF-like) domains.

Emr1 is a transmembrane protein present on the cell-surface of human macrophages, which are derived from the myeloid lineage. It has an approximate mass of 125 kDa, and is associated with mature macrophages.

See also[edit]


  1. ^ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (Aug 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460. 
  2. ^ McKnight AJ, Gordon S (Mar 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". J Leukoc Biol 63 (3): 271–80. PMID 9500513. 
  3. ^ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1". 
  4. ^ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". J. Immunol. Methods 174 (1-2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID 8083537. 
  5. ^ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1–200. ISBN 978-1-4419-7912-4. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.