This gene encodes a protein that is a member of the adhesion-GPCR family.  Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 region via membrane proximal GAIN domain. In the case of EMR1 these domains are Epidermal Growth Factor (EGF-like) domains.
Emr1 is a transmembrane protein present on the cell-surface of human macrophages, which are derived from the myeloid lineage. It has an approximate mass of 125 kDa, and is associated with mature macrophages.
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