Neuromedin B receptor

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Neuromedin B receptor
Identifiers
Symbols NMBR ; BB1
External IDs OMIM162341 MGI1100525 HomoloGene20560 IUPHAR: BB1 ChEMBL: 3636 GeneCards: NMBR Gene
RNA expression pattern
PBB GE NMBR 207333 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4829 18101
Ensembl ENSG00000135577 ENSMUSG00000019865
UniProt P28336 O54799
RefSeq (mRNA) NM_002511 NM_008703
RefSeq (protein) NP_002502 NP_032729
Location (UCSC) Chr 6:
142.38 – 142.41 Mb
Chr 10:
14.76 – 14.77 Mb
PubMed search [1] [2]

The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[2]

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3]

References[edit]

  1. ^ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. ^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  3. ^ "Entrez Gene: NMBR neuromedin B receptor". 

Further reading[edit]

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.". J. Biol. Chem. 266 (28): 18771–9. PMID 1655761. 
  • Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750. 
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). "Expression and characterization of cloned human bombesin receptors.". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  • Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.". Gastroenterology 105 (6): 1672–80. PMID 8253343. 
  • Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. 
  • Fathi Z, Benya RV, Shapira H, et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.". J. Biol. Chem. 268 (20): 14622–6. PMID 8392057. 
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. 
  • Sainz E, Akeson M, Mantey SA, et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639. 
  • Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Matusiak D, Glover S, Nathaniel R, et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.