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Egf-like module containing, mucin-like, hormone receptor-like 3
Symbol EMR3
External IDs OMIM606101 HomoloGene50009 IUPHAR: EMR3 GeneCards: EMR3 Gene
RNA expression pattern
PBB GE EMR3 210724 at tn.png
More reference expression data
Species Human Mouse
Entrez 84658 n/a
Ensembl ENSG00000131355 n/a
UniProt Q9BY15 n/a
RefSeq (mRNA) NM_001289158 n/a
RefSeq (protein) NP_001276087 n/a
Location (UCSC) Chr 19:
14.73 – 14.8 Mb
PubMed search [1] n/a

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein that in humans is encoded by the EMR3 gene.[1]


The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. In the case of EMR3, the N-terminal protein domains consists of 2 epidermal growth factor (EGF)-like domains.[2][3] EMR3 is expressed predominantly by cells of the immune system. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 EMR2 on chromosome 19. The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[4]

See also[edit]


  1. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (May 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J Biol Chem 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  2. ^ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1–200. ISBN 978-1-4419-7912-4. 
  3. ^ Yona, S; Lin, HH; Siu, WO; Gordon, S; Stacey, M (October 2008). "Adhesion-GPCRs: emerging roles for novel receptors.". Trends in Biochemical Sciences 33 (10): 491–500. doi:10.1016/j.tibs.2008.07.005. PMID 18789697. 
  4. ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.