EMR3

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Egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
Symbol EMR3
External IDs OMIM606101 HomoloGene50009 IUPHAR: 184 GeneCards: EMR3 Gene
RNA expression pattern
PBB GE EMR3 210724 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84658 n/a
Ensembl ENSG00000131355 n/a
UniProt Q9BY15 n/a
RefSeq (mRNA) NM_001289158 n/a
RefSeq (protein) NP_001276087 n/a
Location (UCSC) Chr 19:
14.73 – 14.8 Mb
n/a
PubMed search [1] n/a

EGF-like module-containing mucin-like hormone receptor-like 3 also known as ADGRE3 is a protein that in humans is encoded by the EMR3 gene.[1] The gene product is a member of the adhesion GPCR family of receptors.[2] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4][5] EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Interestingly, transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]

Function[edit]

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]

Ligands[edit]

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[10]

References[edit]

  1. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  2. ^ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1–200. ISBN 978-1-4419-7912-4. 
  3. ^ Yona S (2011). Adhesion-GPCRs. Springer. ISBN 978-1-4419-7912-4. 
  4. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-termina] containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  6. ^ Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ et al. (Feb 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056. 
  7. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  8. ^ Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE et al. (Dec 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. 
  9. ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". 
  10. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 

External links[edit]